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This factsheet is about rare types of high-grade B-cell lymphoma that are difficult to classify: grey zone lymphoma; double-hit and triple-hit lymphoma; and high-grade B-cell lymphoma, not otherwise specified (NOS). It covers the following topics: What types of high-grade B-cell lymphoma are difficult to classify?; Grey zone lymphoma; Double-hit and triple-hit lymphoma; High-grade B-cell lymphoma, not otherwise specified (NOS); Treatment; Finding information.