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This factsheet has information on on immunotherapy, a type of treatment being investigated in myeloma. It explains what imunotherapy treatment is, how it works, and the current evidence to support its use in the treatment of myeloma. It describes the main immunotherapies (monoclonal antibody drugs; CAR-T cell treatments; and oncolytic viruses) and their known possible side-effects, and the availability of immunotherapy treatment in the UK.